In the Molecular Neuro-oncology Lab we employ multidisciplinary approaches and outside-the-box thinking to discover mechanisms that regulate plasticity, motility, genome organization and RNA epigenetics of human glioma stem cells.
We are currently focused on the following projects:
RNA epigenetics of human glioma stem cells:
Role of m6A RNA in the regulation of glioma stem cell translation.
Role of lincRNAs and eRNAs in chromatin accessibility and 3D genome organization of glioma stem cells.
Glioma microenvironment, immunomodulation and combination therapies.
Modeling of human glioma stem cell migration – role of glioma cell pseudopodia.
Novel glioma therapies: Methods to attract and trap migrating glioma cells.
3D human glioma spheroids, development of engineered human brain tumor macro-tissues.
Epigenetic Regulation of regenerating Schwann cells
Role of Egr2-AS-RNA in nerve injury response and genome organization of regenerating glia.