Glial cells constitute the majority of the cells in the nervous system and are emerging as major regulators of nervous system development, function, and health. Despite their abundance we know surprisingly little about any aspect of their biological functions.
In the Molecular Neuroscience & Neurooncology Lab we employ multidisciplinary approaches and outside-the-box thinking to discover mechanisms that regulate myelination, plasticity, cellular motility and oncogenic transformation of glial cells.
We are currently focused on the following projects:
Molecular Neuroscience of the PNS
- Role of nuclear ErbB3 in PNS myelination
- Role of Lck during nerve injury response and the generation of the regenerating Schwann cell phenotype
- Identification and role of a natural occurring long antisense RNA against the Egr2 promoter during nerve injury response and in demyelinating diseases
- Molecular Neurooncology
- Modeling of human glioma stem cell migration – role of glioma cell pseudopodia
- Novel glioma therapies: Methods to attract and trap migrating glioma cells
- RNA epigenetics of human Glioma Stem Cells:
- Role of post-transcriptional RNA methylation in the regulation of the functional glioma stem cell proteome.
- Role of antisense RNA in the oncogenic transformation of neural stem cells – origin of cancer in the brain.