In the Cancer Epigenetics and Plasticity Lab we employ outside-the-box thinking to discover mechanisms that regulate cellular plasticity, RNA epigenetics and genome organization of human glioma stem cells.
We are currently focused on the following projects:
Cancer Epigenetics and plasticity in human glioblastoma
Role of m6A RNA in the regulation of cancer stemness - Development of first in class epitranscriptome targeting therapeutics
Enhancer RNA (eRNA) mediated regulation of cancer stem cells - eRNA therapeutics
Role of Histone Deacetylase 7 (HDAC-7) in the regulation of chromatin architecture in glioma stem cells
Transcriptional kinetics defining cancer stem cell plasticity - Epigenetic landscape of brain tumors
Chromatin and enhancer state dynamics of glioma stem cells in hypoxia
Novel methods to attract and trap migrating glioma cells.
Epigenetic Regulation of regenerating Schwann cells
Role of Egr2-AS-RNA in nerve injury response and genome organization of regenerating glia.