In the Cancer Epigenetics and Plasticity Lab we employ outside-the-box thinking to discover mechanisms that regulate cellular plasticity, RNA epigenetics and genome organization of human glioma stem cells.

We are currently focused on the following projects:

  • Cancer Epigenetics and plasticity in human glioblastoma

    • Role of m6A RNA in the regulation of cancer stemness - Development of first in class epitranscriptome targeting therapeutics

    • Enhancer RNA (eRNA) mediated regulation of cancer stem cells - eRNA therapeutics

    • Role of Histone Deacetylase 7 (HDAC-7) in the regulation of chromatin architecture in glioma stem cells

    • Transcriptional kinetics defining cancer stem cell plasticity - Epigenetic landscape of brain tumors

    • Chromatin and enhancer state dynamics of glioma stem cells in hypoxia

    • Novel methods to attract and trap migrating glioma cells.

  • Epigenetic Regulation of regenerating Schwann cells

    • Role of Egr2-AS-RNA in nerve injury response and genome organization of regenerating glia.

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